![]() Side effects in the former courses and latter courses were compared taking into account a stratification of intervals. To investigate whether the association between interval and treatment response could be modified by RAI treatment times, we performed a stratified analysis by RAI treatment times of the former course (second, third and fourth, and fifth and more). Therefore, the overall treatment response in the latter course was determined to be an effective response if SD or remission was obtained according to biochemical and structural response if either of biochemical response or structural response assessment indicated PD, the treatment response was determined to be a non-effective response. Meanwhile, the structural response in the latter course was categorized as structural CR, PR, SD, and PD, according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1-like criteria ( 20, 21). Eligible course pairs were then categorized into two groups according to the interval between courses: 1) −25.0% and ≤ 25.0% indicated stable disease (SD), and Δs-Tg% > 25.0% indicated progressive disease (PD). DTC patients with lung metastases have a relatively poorer prognosis than those without metastases, with a median survival of 60.0 IU/ml 4) course pairs with an interval >24 months because of poor compliance and 5) course pairs with missing treatment data. It was feasible to defer repeat evaluation and treatment with an interval of at least 12 months to obtain an effective response and reduce the risk of side effects.Īpproximately 10% of patients with differentiated thyroid cancer (DTC) have distant metastases at presentation or during follow-up, and their lungs are the most common organ of distant metastases, accounting for 70% of distant metastasis cases ( 1, 2). There was no significant difference in the side effects in the former and latter courses between the two groups (p > 0.05).Ĭonclusion: The interval of RAI treatment does not affect short-term response and side effects of DTC patients with RAI-avid lung metastases. Methods: A total of 282 course pairs from 91 patients were established and categorized into two groups by the interval of neighboring RAI treatment ( 0.05). We aim to investigate the association between the interval of RAI treatment and short-term response, and the side effects in patients with lung metastases from DTC and to identify predictors for non-effective response to the next RAI treatment. Objective: Repeat radioiodine (RAI) treatment has been widely implemented for RAI-avid lung metastases and is clinically effective for lung metastatic differentiated thyroid cancer (DTC). 2Department of Nuclear Medicine, Chengdu Fifth People’s Hospital, Chengdu, Sichuan, China.1Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Hongxi Wang 1†, Lei Shi 2†, Rui Huang 1, Bin Liu 1 and Rong Tian 1*‡
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![]() Remember the relationship between the Song Editor and the Beat Editor: if you switch the beat sequence ON for one bar in the Song Editor, then only four bars of your sequence will play. You can sequence the default four bars of four beats, or you can add more bars if you want to sequence longer sections. You're free to sequence during playback, so if you're the type of programmer who likes to hear the changes you're making as you make them, just press play and programme on the fly. Drag and drop samples from the Samples tab into the Beat+Bassline editor, and start building some beats. To sequence this batch of samples, click the first block in the Beat/Bassline 0 track of your Song Editor. A full General Midi compliant drumkit is ready for use. Click on the My Samples tab on the left side of the LMMS window and open the Drums folder. LMMS comes with all you need for drum sequencing out of the box. You'll find plenty to play with in these tabs, and of course you can add more. Click on them to see for yourself what they contain. On the far left of the LMMS window is a stack of tabbed panels, collapsed by default. If you have no idea what you are, then you might as well try a little of everything. If you're a synthesist, you might noodle around with some of the soft synths until you reach LFO nirvana. If you're a skilled musician, you might use sample banks or soundfonts and a MIDI keyboard to play in your own sequences. If you're a loop-driven producer, you will most likely deal mostly with sample tracks. Your individual style and workflow depends entirely on what kind of music producer you are. These are just starting points, provided only to give you an idea of what's possible and where to begin. All of the other windows that you interact with exist in relation to the Song Editor, so use it as your main compositional hub.īy default, the Song Editor pre-populates four channels: This is its sequencer, where you plug in new instruments, samples, drum lines, and automation. The centre of the LMMS interface is its Song Editor window. Best of all, LMMS comes with many ready-to-use instrument and effect plug-ins, presets, and samples, making it one of the easiest music applications on any platform to get started on. It's an everything-including-the-kitchen-sink apps, providing you with all the tools you need to create melodies, lay down a beat (mad, phat, dope, or otherwise), synthesize new sounds, sample, loop, distort, enhance, and, of course, mix it all together. LMMS is a free end-to-end, cross-platform music production suite. In the world of digital audio workstations, the project that does this most profoundly is the Linux Multimedia Studio, better known as LMMS. That's why it's nice, sometimes, to come across a project that brings a bunch of modular technology and binds them together nice and neatly for users. It turns out to be liberating in the end, but it can be overwhelming at first. One thing that confuses some new Linux users is just how modular Linux can be, and on nearly every level. ![]() New features will be added in the following updates. ![]() ![]() New maps and an improved weather system provide a fascinating gaming experience.Checking tire pressure, coolant, and lubricant levels, buying used trucks, and changing engines, gearboxes, differentials, tires, and rims are some new features that GTS 2 offers us.A new physics with realistic consumption, damage, and wear will test all your driving and management skills.Now more than ever, you must take care of your fleet of vehicles.The second edition of the Grand Truck Simulator saga brings a new concept to mobile logistics simulation.For example, signals, car lights, car horns, steering wheel,? KEY FEATURES The console is designed with on-screen floating keys, neatly paired on both sides of the screen, and players only need to tap to use it. Each function section is organized logically and minimally. But first, it was straightforward to help adapt quickly to the gameplay and driving experience.įirst, the publisher has developed a relatively intuitive and user-friendly interface regarding the interface. This setting is quite reasonable Delivery distances can vary in length and complexity. New maps and areas will then be unlocked to continue your game. You will perform missions and explore all the places in different countries. Your journey around the world will begin in a beautiful country. EXPLORE ALL THE PLACES IN DIFFERENT COUNTRIES And they will pay you every time you complete the trip. And, of course, you are a driver your job is to transport goods from businesses to customers. Have you ever wished to be a truck driver, transport goods, and travel worldwide? Grand Truck Simulator 2 Will help you realize this dream and become a truck driver. This is the famous simulation truck-driving game released by Pulsar Gamesoft. You may feel unreliable, but you will soon be convinced of Grand Truck Simulator 2. For example, the World Truck Driving Simulator has been released on mobile, PC, and heavy truck simulators. However, the experience it brings is not inferior to any PC game, usually in gameplay and graphics. Grand Truck Simulator 2 MOD APK Simulation games are slowly gaining popularity on mobile platforms. ![]() He wins the hand of a Martian princess, Dejah Thoris of Helium, but after several years of marriage he sacrifices himself to save Barsoom from the loss of its atmosphere. He finds his true calling in life as a warlord who strives to save the planet's inhabitants. On Mars, which its natives call Barsoom, Carter encounters both formidable alien creatures resembling the beasts of ancient myth, and various humanoids. Accustomed to the greater gravity of Earth, he finds himself to be much stronger and more agile than the natives of Mars. While hiding from Apaches in a cave, he appears to die leaving his inanimate body behind, he is mysteriously transported by a form of astral projection to the planet Mars, where he finds himself re-embodied in a form identical to his earthly one. Carter and Powell struck it rich by finding gold in Arizona. After the war, Carter and his companion Powell, who was also a captain in the Civil War, became gold prospectors. A Virginian, he served as a captain in the American Civil War on the side of the Confederacy. ![]() His character and courtesy exemplify the ideals of the Antebellum South. Many generations have known him as "Uncle Jack," but he always lived to see them grow old and die, while he remained young. In the opening pages of A Princess of Mars, it is revealed that Carter can remember no childhood, having always been a man of about thirty years old. Description Ĭarter stands 6 feet 2 inches (1.88 m) and has close-cropped black hair and steel-grey eyes. Considered the 12th book in the Barsoom series, it is officially seen as canon. released John Carter Of Mars: Gods of the Forgotten, by Geary Gravel. In September 2021, Edgar Rice Burroughs, Inc. John Carter is also a major secondary character in the fourth volume ( Thuvia, Maid of Mars, 1920), and the ninth ( Synthetic Men of Mars, 1940). McClurg & Company, the novel was retitled A Princess of Mars.Ĭarter reappeared in subsequent volumes of the series, most prominently in the second ( The Gods of Mars, 1918), the third ( The Warlord of Mars, 1919), the eighth ( Swords of Mars, 1936), the tenth ( Llana of Gathol, 1948), and the eleventh and final installment ( John Carter of Mars, published posthumously in 1964). For its October 1917 hardcover publication by A.C. It later appeared as a complete novel only after the success of Burroughs's Tarzan series. Written between July and September 28, 1911, the novel was serialized as Under the Moons of Mars in the pulp magazine The All-Story from February to July 1912. John Carter was the lead character in the first novel by Edgar Rice Burroughs, set on a fictionalized version of Mars known as Barsoom. Created in 1911, the character has appeared in novels and short stories, comic books, television shows and films, including the 2012 feature film John Carter, which marked the 100th anniversary of the character's first appearance. A veteran of the American Civil War, he is transported to the planet Mars, called Barsoom by its inhabitants, where he becomes a warrior battling various mythological beasts, alien armies and malevolent foes. John Carter of Mars is a fictional Virginian soldier who acts as the initial protagonist of the Barsoom stories by Edgar Rice Burroughs. ![]() A Princess of Mars was possibly the first fiction of the 20th century to feature a constructed language although Barsoomian was not particularly developed, it did add verisimilitude to the narrative.John Carter and Dejah Thoris from the cover of the first edition of A Princess of Mars by Edgar Rice Burroughs, McClurg, 1917 Several sequels followed, filling out his vision of Barsoom and developing it in more detail. In 1911, Burroughs, now better known as the creator of the character Tarzan, began his writing career with A Princess of Mars, a rousing tale of pulp adventure set on the planet. This book-collection file includes: A Princess of Mars, 1912 (the book that the movie "John Carter" was based on) The Gods of Mars, 1914 The Warlord of Mars, 1918 Thuvia, Maid of Mars, 1920 and The Chessmen of Mars, all of which are in the "Barsoom" series.According to Wikipedia: "Edgar Rice Burroughs (Septem– March 19, 1950) was an American author, best known for his creation of the jungle hero Tarzan and the heroic John Carter, although he produced works in many genres." Also according to Wikipedia: "Barsoom is a fictional version of the planet Mars invented by author Edgar Rice Burroughs for a series of action adventure stories. ![]() ![]() "We were not prepared for this," said Berchtesgadener Land district administrator Bernhard Kern, adding that the situation had deteriorated "drastically" late on Saturday, leaving little time for emergency services to act.Ībout 110 people have been killed in the worst-hit Ahrweiler district south of Cologne. Hundreds of rescue workers were searching for survivors in the district, which borders Austria. Roads were turned into rivers, some vehicles were swept away and swathes of land buried under thick mud in Berchtesgadener Land. "The German language can barely describe the devastation that's taken place."Īs efforts continued to track down missing people, the devastation continued on Sunday when a district of Bavaria, southern Germany, was hit by flash floods that killed at least one person. "It is terrifying," she told residents of the small town of Adenau in the state of Rhineland-Palatinate. She also said governments would have to get better and faster in their efforts to tackle the impact of climate change only days after Europe outlined a package of steps towards "net zero" emissions by the middle of the century. Merkel promised swift financial aid after visiting one of the areas worst affected by the record rainfall and floods that have killed at least 157 in Germany alone in recent days, in the country's worst natural disaster in almost six decades. BERCHTESGADEN/BISCHOFSWIESEN, Germany, July 18 (Reuters) - German Chancellor Angela Merkel described the flooding that has devastated parts of Europe as "terrifying" on Sunday after the death toll across the region rose to 188 and a district of Bavaria was battered by the extreme weather. No offer to buy nor sell any instrument is being made on this site. By accessing this site and its products/services you agree to all terms of our Disclaimer. Consult with a registered investment advisor prior to making trading and/or investment decisions. We are a publisher of educational content. We are not an investment advisor, financial planner nor registered broker. Trading is a high-risk, speculative activity. No profitability nor performance claims of any kind are being made. ![]() Disclaimer: All information provided herein is published for educational purposes only and should not be construed as investment advice. ![]() We make no profitability nor performance claims of any kind all information is published for educational use only. Past performance is not necessarily indicative of future results. ![]() Only risk capital should be used for trading and only those with sufficient risk capital should consider trading. Risk capital is money that can be lost without jeopardizing ones’ financial security or life style. An investor could potentially lose all or more than the initial investment. Individuals must consider all relevant risk factors including their own personal financial situation before trading. Risk Disclosure: The risk of loss trading securities, futures, forex, and options can be substantial and is not for every investor. The only service this platform provides is to compare different lenders ' offers, and it is not responsible for the services provided by parties. No financial decisions are made by the website. The lenders or other broker services we introduce to our customers through this website may pay us commissions if customers enter into a credit agreement with them.ĭisclaimer: This platform does not offer or insist on borrowing money. NOT A LENDER Disclosure: WeLoans is not a lender but a broker and does not charge you any fees for our broker services. ![]() Rules of this website are subject to change without notifications. Please check the local regulations to find out its availability in the area. A borrower also has to peruse local regulations related to a payday loan.Īvailability: The service of this platform may not be accessible to people based in restricted states. ![]() Those who find themselves in a bind with their budget and want to refill it with credits should seek the advice of a professional financial assistant. It's a short-term solution to cover unexpected expenses when people have no savings or deep pockets. ![]() WeLoans is a company committed to connecting borrowers to hundreds of reputable online lenders to apply and get small-dollar payday loans quickly, easily, and securely, helping cope with life emergencies like paying medical bills, home, or car repairs, and so on.Ĭustomer Note: A payday loan is traditionally used to help people borrow a small sum of money until the next upcoming payday. ![]() Clipper made in Hungary, blade made in USA. Ideal for all animal coats including dogs, cats, horses, and livestock. Wahls® KM5® Professional 2-Speed Clippers offer the efficiency of Constant Speed Controlbuilt-in torque control that automatically delivers more power when clipping through mats and thick coats, making quick work of tough situations. The KM Cordless combines the KM10 signature Brushless Motor with Lithium Ion. Includes a #10 Ultimate Competition Series detachable blade and a 10 foot heavy duty charging cord. Cut the cord with the new Wahl KM Cordless 2-speed professional clipper. The KM Cordless combines the KM10 signature Brushless Motor with Lithium Ion technology to bring you Wahl's very first detachable blade cordless clipper Work all day with a 2-hour cordless run time and cord/cordless capability. Quick Charge feature provides 15 extra minutes of clipping for every 10 minutes it charges.īest of all, the KM Cordless comes with a 5 Year Hassle Free Warranty that includes Accidental Damage Protection and Free Shipping to and from Wahl’s Service & Repair Center! 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Cooperation was actively encouraged, a technique that allowed the intentions and progress of each team to be communicated in regular open-room meetings. In addition, rather than allowing each development and production department to work in isolation, Yoshida instigated the idea of a common goal. This included the exterior design, which, for the first time in the car’s history, was penned in Europe. Working from an all-new platform, every area of the ninth-generation Corolla was developed afresh from a different perspective. So instead of developing the car to meet the needs of high-volume markets such as the United States, it was primarily designed to appeal to the most demanding world market – Europe. They had to break away from class concepts and target high standards in design, performance and quality. Yoshida pondered for a long time about how to change this mind set, coming to the conclusion that the development team needed to start again from scratch. However, I believed that if a manufacturer is overly concerned about failure and ultimately places priority on cost and ease of production, it will end up making a product that is convenient for themselves.” Yoshida shed light on the feeling of the time when he commented: “I constantly heard about how the Corolla was a can’t fail vehicle for Toyota. In order to achieve this, Toyota realised that the new car shouldn’t simply rework long-standing designs and values it needed to proactively protect the respected Corolla brand by introducing new, thoroughly modern priorities that harmonised with the moved goalposts of the New Millennium. In the face of this changing financial marketplace, it was vital that Corolla continued the success of its predecessors yet evolved to appeal once again to a broad range of car-buyers. What’s more, the consumers that actually were in a position to buy a new car were getting older. The economy was sluggish, and families were beginning to prefer compact multi-purpose vehicles (MPVs) over traditional body styles. Work began on the next-generation Corolla in the late Nineties – a difficult period for the Japanese car industry. Despite the fact that Corolla production had recently exceeded 28 million units and that it accounted for 20% of Toyota’s entire annual sales worldwide, he wanted to put together a car that broke the link with Corolla models of the past and constructed a new global standard for the 21st Century. In developing the ninth-generation Toyota Corolla, chief engineer Takeshi Yoshida gave himself a risky and unenviable task. |
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